As the UN's only cosponsored Joint Programme, UNAIDS has spearheaded a coordinated, multisectoral HIV response for nearly 30 years. The 2021 UN Political Declaration on HIV and AIDS, supported by UNAIDS' Global AIDS Strategy 2021-2026, charts a clear path to end AIDS as a public health threat by 2030. Taking this path is a sound political and financial choice that will save lives.