Compared with clinical or immunological monitoring, viral load provides an early and more accurate indication of treatment failure. Measuring viral load can help to distinguish between drug resistance and non-adherence when coupled with robust enhanced adherence counselling. Further, viral load can serve as a proxy measure for the risk of transmission and effectiveness of prevention interventions at both the individual and population levels.
Increasing scale-up of treatment monitoring approaches through viral load testing as well as infant diagnosis will be critical to ensure high-quality care and treatment as well as programmatic success.